Purification:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Nuclear Magnetic Resonance:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
High Performance Liquid Chromatography:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Residue:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Column Chromatography:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Reversed-phase Chromatography:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Cream:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
Irradiation:Article Title: Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
Article Snippet: The reaction mixture was then cooled to room temperature, concentrated and purified by biotage (75% ethyl acetate:hexanes) to afford the tittle compound as a solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-40% EtOAc in petrol as the eluent gave the title compound as a colourless oil (205 mg, 45%); 1H NMR (500 MHz, CDCl3) 0.13-0.17 (2H, m) 0.39-0.43 (2H, m), 1.11 (21H, s), 2.67-2.69 (4H, m), 2.77 (1H, d), 3.35 (1H, d), 3.50 (1H, d), 4.21 (1H, d), 4.59 (1H, d), 7.12-7.13 (2H, m), 7.17-7.26 (5H, m), 7.28 (2H, m), 8.14-8.15 (1H, m), 8.43-8.44 (1H, m).
Article Title: Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-50% EtOAc in petrol gave (3R)-3-(4-chlorophenyl)-2-((5-chloropyridin-2-yl)methyl)-6-(1-hydroxy-1-(1-tosyl-1H-pyrazol-5-yl)ethyl)-3-methoxyisoindolin-1-one (76 mg).
Article Title: Inhibitors of human immunodeficiency virus replication
Article Snippet: The reaction mixture was diluted with CH2Cl2 (100 mL), washed with water (4×25 mL), brine (25 mL), dried (Na2SO4), filtered, concentrated and purified by biotage (0-40% EtOAc/Hex) to afford methyl 4-(4,4-dimethylpiperidin-1-yl)-5-(2-methoxy-2-oxoacetyl)-6-methylpyrazolo[1,5-a]pyridine-2-carboxylate (1.2 g, 3.10 mmol, 65.7% yield) as light solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-100% EtOAc in petrol as the eluent gave a diastereoisomeric mixture of product (177 mg, 18%).
Article Title: Activators of glucokinase
Article Snippet: NaHCO3, dried over MgSO4, filtrated, concentrated, purified by Biotage (80% EtOAc) to give (5-formyl-thiophen-2-yl)-phosphonic acid diethyl ester (7.2 g, 48.3%).
Article Title: Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Article Snippet: The reaction mixture was purified by biotage eluting with 1% to 10% MeOH in DCM to afford (5S,12S,165)-tri-tert-butyl 5-(4-(bis((1-(2-tert-butoxy-2-oxoethyl)-1H-imidazol-2-yl)methyl)amino)butyl)-1-(9H-fluoren-9-yl)-3,6,14-trioxo-2-oxa-4,7,13,15-tetraazaoctadecane-12,16,18-tricarboxylate (85.7 mg, 35%) as a white solid.
Article Title: Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Article Snippet: Purified by Biotage using 0-30% MeOH in EtOAc as the eluent gave the title compound as a colourless oil (407 mg, 35%).
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